i make all my prints with affinity designer. it's not perfect at all but i find it really intuitive, and it costs £60 one time rather than adobe who make you sign over your firstborn. individually dragging around little vector nodes feels like doodling in your workbook in highschool.
i've not actually printed any of them yet, but it's definitely on the cards. i'd really like to learn screenprinting, but actually finding somewhere in london where you can do it yourself is harder than you'd think. watch this space!